LeRoy Nellis

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Tag: fatigue reduction

  • Caffeine — The Neurochemical Study of Focus, Fatigue, and Friction

    SUBTITLE: Pharmacology, Performance, Sleep, and Strategy for the Loopwired SystemAUTHOR: LeRoy Nellis (Project: LOOPWIRED)VERSION: 1.0 (2025-10-09) ─────────────────────────────────────────────I. EXECUTIVE SUMMARY─────────────────────────────────────────────Caffeine is the world’s most used psychoactive compound. It enhances alertness and performance primarily by antagonizing adenosine receptors (A1, A2A), reducing perceived effort and sleep pressure. In the Loopwired model, caffeine is a **temporary attentional accelerator** that…